Human Brain Imaging and Radiation Dosimetry of (11)C-N-Desmethyl-Loperamide, a PET Radiotracer to Measure the Function of P-Glycoprotein

P-glycoprotein (P-gp) is a membrane-bound efflux pump that limits the distribution of drugs to several organs of the body. At the blood–brain barrier, P-gp blocks the entry of both loperamide and its metabolite, N-desmethyl-loperamide (N-dLop), and thereby prevents central opiate effects. Animal stu...

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Hlavní autoři: Seneca, Nicholas, Zoghbi, Sami S., Liow, Jeih-San, Kreisl, William, Herscovitch, Peter, Jenko, Kimberly, Gladding, Robert L., Taku, Andrew, Pike, Victor W., Innis, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792991/
https://ncbi.nlm.nih.gov/pubmed/19372478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.108.058453
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