Design and Profiling of GS-9148, a Novel Nucleotide Analog Active against Nucleoside-Resistant Variants of Human Immunodeficiency Virus Type 1, and Its Orally Bioavailable Phosphonoamidate Prodrug, GS-9131

GS-9148 [(5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl)phosphonic acid] is a novel ribose-modified human immunodeficiency virus type 1 (HIV-1) nucleotide reverse transcriptase (RT) inhibitor (NRTI) selected from a series of nucleoside phosphonate analogs for its favorable in vitro...

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Autori principali: Cihlar, Tomas, Ray, Adrian S., Boojamra, Constantine G., Zhang, Lijun, Hui, Hon, Laflamme, Genevieve, Vela, Jennifer E., Grant, Deborah, Chen, James, Myrick, Florence, White, Kirsten L., Gao, Ying, Lin, Kuei-Ying, Douglas, Janet L., Parkin, Neil T., Carey, Anne, Pakdaman, Rowchanak, Mackman, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224772/
https://ncbi.nlm.nih.gov/pubmed/18056282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01215-07
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