Double-stranded regions are essential design components of potent inhibitors of RISC function

While microRNAs (miRNAs) are recognized as playing a critical role in regulating eukaryotic gene expression, both the mechanism by which these small, noncoding RNAs function and the genes they target remain elusive. Previous studies have shown that short, single-stranded 2′-O-methyl-modified oligonu...

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Detalhes bibliográficos
Main Authors: Vermeulen, Annaleen, Robertson, Barbara, Dalby, Andrew B., Marshall, William S., Karpilow, Jon, Leake, Devin, Khvorova, Anastasia, Baskerville, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1852807/
https://ncbi.nlm.nih.gov/pubmed/17400817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.448107
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