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The contributions of dsRNA structure to Dicer specificity and efficiency

Dicer processes long double-stranded RNA (dsRNA) and pre-microRNAs to generate the functional intermediates (short interfering RNAs and microRNAs) of the RNA interference pathway. Here we identify features of RNA structure that affect Dicer specificity and efficiency. The data presented show that va...

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Autors principals: VERMEULEN, ANNALEEN, BEHLEN, LINDA, REYNOLDS, ANGELA, WOLFSON, ALEXEY, MARSHALL, WILLIAM S., KARPILOW, JON, KHVOROVA, ANASTASIA
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2005 by RNA Society 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370754/
https://ncbi.nlm.nih.gov/pubmed/15811921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7272305
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