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Induction of the interferon response by siRNA is cell type– and duplex length–dependent
Long (27–29-bp dsRNA) Dicer-dependent substrates have been identified as potent mediators of RNAi-induced gene knockdown in HEK293 and HeLa cells. As the lengths of these molecules are reported to be below the threshold generally regarded as necessary for induction of the mammalian interferon (IFN)...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464853/ https://ncbi.nlm.nih.gov/pubmed/16611941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2340906 |
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