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Experimental validation of the importance of seed complement frequency to siRNA specificity
Pairing between the hexamer seed region of a small interfering RNA (siRNA) guide strand (nucleotides 2–7) and complementary sequences in the 3′ UTR of mature transcripts has been implicated as an important element in off-target gene regulation and false positive phenotypes. To better understand the...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2327361/ https://ncbi.nlm.nih.gov/pubmed/18367722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.704708 |
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