Off-target effects by siRNA can induce toxic phenotype

Although recent microarray studies have provided evidence of RNA interference (RNAi)-mediated off-target gene modulation, little is known about whether these changes induce observable phenotypic outcomes. Here we show that a fraction of randomly selected small inhibitory RNAs (siRNAs) can induce cha...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Fedorov, Yuriy, Anderson, Emily M., Birmingham, Amanda, Reynolds, Angela, Karpilow, Jon, Robinson, Kathryn, Leake, Devin, Marshall, William S., Khvorova, Anastasia
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2006
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484448/
https://ncbi.nlm.nih.gov/pubmed/16682561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.28106
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires