Off-target effects by siRNA can induce toxic phenotype

Although recent microarray studies have provided evidence of RNA interference (RNAi)-mediated off-target gene modulation, little is known about whether these changes induce observable phenotypic outcomes. Here we show that a fraction of randomly selected small inhibitory RNAs (siRNAs) can induce cha...

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Detalhes bibliográficos
Main Authors: Fedorov, Yuriy, Anderson, Emily M., Birmingham, Amanda, Reynolds, Angela, Karpilow, Jon, Robinson, Kathryn, Leake, Devin, Marshall, William S., Khvorova, Anastasia
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484448/
https://ncbi.nlm.nih.gov/pubmed/16682561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.28106
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