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Dicer uses distinct modules for recognizing dsRNA termini
Invertebrates rely on Dicer to cleave viral dsRNA, and Drosophila Dicer-2 distinguishes dsRNA substrates by their termini. Blunt termini promote processive cleavage, while 3’ overhanging termini are cleaved distributively. To understand this discrimination, we used cryo-electron microscopy to solve...
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| Publicado en: | Science |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6154394/ https://ncbi.nlm.nih.gov/pubmed/29269422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaq0921 |
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