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Crystal structure of human stem cell factor: Implication for stem cell factor receptor dimerization and activation

Stem cell factor (SCF) plays important roles in hematopoiesis and the survival, proliferation, and differentiation of mast cells, melanocytes, and germ cells. SCF mediates its biological effects by binding to and activating a receptor tyrosine kinase designated c-kit or SCF receptor. In this report...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhang, Zhongtao, Zhang, Rongguang, Joachimiak, Andrzej, Schlessinger, Joseph, Kong, Xiang-Peng
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16613/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10884405/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.14.7732
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