CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Abstract Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy. Yet, room for improvement remains, especially for the latest LV generations delivering...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2023-12-01
Цуврал:	Advanced Science
Нөхцлүүд:	CAR T cells IFITM in vivo gene delivery rapamycin receptor‐targeted vectors transduction enhancer
Онлайн хандалт:	https://doi.org/10.1002/advs.202302992
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!