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Anti-CD19 CARs displayed at the surface of lentiviral vector particles promote transduction of target-expressing cells

Recently, a rare type of relapse was reported upon treating a B cell acute lymphoblastic leukemia (B-ALL) patient with anti-CD19 chimeric antigen receptor (CAR)-T cells caused by unintentional transduction of residual malignant B cells (CAR-B cells). We show that anti-CD19 and anti-CD20 CARs are pre...

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Principais autores: Nicole Cordes, Carolin Kolbe, Dominik Lock, Tatjana Holzer, Deborah Althoff, Daniel Schäfer, Franziska Blaeschke, Bettina Kotter, Sandra Karitzky, Claudia Rossig, Toni Cathomen, Tobias Feuchtinger, Iris Bürger, Mario Assenmacher, Thomas Schaser, Andrew D. Kaiser
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-06-01
Serier:Molecular Therapy: Methods & Clinical Development
Fag:
CAR-T
CAR-B
immunotherapy
lentiviral vector
CAR display
CAR-T cell resistance
Online adgang:http://www.sciencedirect.com/science/article/pii/S2329050121000280
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