CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms

Abstract Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T cells, a major breakthrough in cancer therapy. Yet, room for improvement remains, especially for the latest LV generations delivering...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Filippos T Charitidis, Elham Adabi, Naphang Ho, Angela H Braun, Ciara Tierney, Lisa Strasser, Frederic B Thalheimer, Liam Childs, Jonathan Bones, Colin Clarke, Christian J Buchholz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2023-12-01
Schriftenreihe:	Advanced Science
Schlagworte:	CAR T cells IFITM in vivo gene delivery rapamycin receptor‐targeted vectors transduction enhancer
Online-Zugang:	https://doi.org/10.1002/advs.202302992
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!