Engineering switchable and programmable universal CARs for CAR T therapy
Abstract A traditional chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen epitope. This rigid design limits clinical application and leads to exceptionally high manufacturing cost. New CARs are being engineered with a modular approach so that...
Wedi'i Gadw mewn:
| Prif Awduron: | , , |
|---|---|
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
BMC
2019-07-01
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| Cyfres: | Journal of Hematology & Oncology |
| Pynciau: | |
| Mynediad Ar-lein: | http://link.springer.com/article/10.1186/s13045-019-0763-0 |
| Tagiau: |
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