Gene duplications resulting in over expression of glucokinase are not a common cause of hypoglycaemia of infancy in humans

von van de Bunt, Martijn, Edghill, Emma L., Hussain, Khalid, Ellard, Sian, Gloyn, Anna L.
Veröffentlicht 2008

A Multi-tissue Transcriptome Analysis of Human Metabolites Guides Interpretability of Associations Based on Multi-SNP Models for Gene Expression

von Ndungu, Anne, Payne, Anthony, Torres, Jason M., van de Bunt, Martijn, McCarthy, Mark I.
Veröffentlicht in Am J Hum Genet (2020)

Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci

von van de Bunt, Martijn, Cortes, Adrian, Brown, Matthew A., Morris, Andrew P., McCarthy, Mark I.
Veröffentlicht in PLoS Genet (2015)

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

von Kailey, Balrik, van de Bunt, Martijn, Cheley, Stephen, Johnson, Paul R., MacDonald, Patrick E., Gloyn, Anna L., Rorsman, Patrik, Braun, Matthias
Veröffentlicht 2012

Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model

von van de Bunt, Martijn, Lako, Majlinda, Barrett, Amy, Gloyn, Anna L., Hansson, Mattias, McCarthy, Mark I., Beer, Nicola L., Honoré, Christian
Veröffentlicht in Islets (2016)

Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans

von Beer, Nicola L., van de Bunt, Martijn, Colclough, Kevin, Lukacs, Christine, Arundel, Paul, Chik, Constance L., Grimsby, Joseph, Ellard, Sian, Gloyn, Anna L.
Veröffentlicht 2011

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

von Thomsen, Soren K, Ceroni, Alessandro, van de Bunt, Martijn, Burrows, Carla, Barrett, Amy, Scharfmann, Raphael, Ebner, Daniel, McCarthy, Mark I, Gloyn, Anna L
Veröffentlicht in Diabetes (2016)

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition

von Perez-Alcantara, Marta, Honoré, Christian, Wesolowska-Andersen, Agata, Gloyn, Anna L., McCarthy, Mark I., Hansson, Mattias, Beer, Nicola L., van de Bunt, Martijn
Veröffentlicht in Diabetologia (2018)

Identification and Functional Characterisation of Novel Glucokinase Mutations Causing Maturity-Onset Diabetes of the Young in Slovakia

von Valentínová, Lucia, Beer, Nicola L., Staník, Juraj, Tribble, Nicholas D., van de Bunt, Martijn, Hučková, Miroslava, Barrett, Amy, Klimeš, Iwar, Gašperíková, Daniela, Gloyn, Anna L.
Veröffentlicht 2012

Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data

von Fernández-Tajes, Juan, Gaulton, Kyle J., van de Bunt, Martijn, Torres, Jason, Thurner, Matthias, Mahajan, Anubha, Gloyn, Anna L., Lage, Kasper, McCarthy, Mark I.
Veröffentlicht in Genome Med (2019)

Deep learning reveals 3D atherosclerotic plaque distribution and composition

von Jurtz, Vanessa Isabell, Skovbjerg, Grethe, Salinas, Casper Gravesen, Roostalu, Urmas, Pedersen, Louise, Hecksher-Sørensen, Jacob, Rolin, Bidda, Nyberg, Michael, van de Bunt, Martijn, Ingvorsen, Camilla
Veröffentlicht in Sci Rep (2020)

The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis

von van de Bunt, Martijn, Gaulton, Kyle J., Parts, Leopold, Moran, Ignasi, Johnson, Paul R., Lindgren, Cecilia M., Ferrer, Jorge, Gloyn, Anna L., McCarthy, Mark I.
Veröffentlicht 2013

Colocalization of GWAS and eQTL Signals Detects Target Genes

von Hormozdiari, Farhad, van de Bunt, Martijn, Segrè, Ayellet V., Li, Xiao, Joo, Jong Wha J., Bilow, Michael, Sul, Jae Hoon, Sankararaman, Sriram, Pasaniuc, Bogdan, Eskin, Eleazar
Veröffentlicht in Am J Hum Genet (2016)

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet

von Kellard, Joely A., Rorsman, Nils J.G., Hill, Thomas G., Armour, Sarah L., van de Bunt, Martijn, Rorsman, Patrik, Knudsen, Jakob G., Briant, Linford J.B.
Veröffentlicht in Mol Metab (2020)

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

von Hastoy, Benoît, Godazgar, Mahdieh, Clark, Anne, Nylander, Vibe, Spiliotis, Ioannis, van de Bunt, Martijn, Chibalina, Margarita V., Barrett, Amy, Burrows, Carla, Tarasov, Andrei I., Scharfmann, Raphael, Gloyn, Anna L., Rorsman, Patrik
Veröffentlicht in Sci Rep (2018)

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

von Pal, Aparna, Barber, Thomas M., Van de Bunt, Martijn, Rudge, Simon A., Zhang, Qifeng, Lachlan, Katherine L., Cooper, Nicola S., Linden, Helen, Levy, Jonathan C., Wakelam, Michael J.O., Walker, Lisa, Karpe, Fredrik, Gloyn, Anna L.
Veröffentlicht 2012

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling

von Ramond, Cyrille, Beydag-Tasöz, Belin Selcen, Azad, Ajuna, van de Bunt, Martijn, Petersen, Maja Borup Kjær, Beer, Nicola L., Glaser, Nicolas, Berthault, Claire, Gloyn, Anna L., Hansson, Mattias, McCarthy, Mark I., Honoré, Christian, Grapin-Botton, Anne, Scharfmann, Raphael
Veröffentlicht in Development (2018)

Insights Into the Pathogenicity of Rare Missense GCK Variants From the Identification and Functional Characterization of Compound Heterozygous and Double Mutations Inherited in Cis

von Beer, Nicola L., Osbak, Kara K., van de Bunt, Martijn, Tribble, Nicholas D., Steele, Anna M., Wensley, Kirsty J., Edghill, Emma L., Colcough, Kevin, Barrett, Amy, Valentínová, Lucia, Rundle, Jana K., Raimondo, Anne, Grimsby, Joseph, Ellard, Sian, Gloyn, Anna L.
Veröffentlicht 2012

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors

von van de Bunt, Martijn, Manning Fox, Jocelyn E., Dai, Xiaoqing, Barrett, Amy, Grey, Caleb, Li, Lei, Bennett, Amanda J., Johnson, Paul R., Rajotte, Raymond V., Gaulton, Kyle J., Dermitzakis, Emmanouil T., MacDonald, Patrick E., McCarthy, Mark I., Gloyn, Anna L.
Veröffentlicht in PLoS Genet (2015)

Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci

von Thurner, Matthias, van de Bunt, Martijn, Torres, Jason M, Mahajan, Anubha, Nylander, Vibe, Bennett, Amanda J, Gaulton, Kyle J, Barrett, Amy, Burrows, Carla, Bell, Christopher G, Lowe, Robert, Beck, Stephan, Rakyan, Vardhman K, Gloyn, Anna L, McCarthy, Mark I
Veröffentlicht in eLife (2018)