Colocalization of GWAS and eQTL Signals Detects Target Genes

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual’s disease risk through their effect on gene expression in different tissues. In order to understand the mechanisms d...

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Dettagli Bibliografici
Pubblicato in:Am J Hum Genet
Autori principali: Hormozdiari, Farhad, van de Bunt, Martijn, Segrè, Ayellet V., Li, Xiao, Joo, Jong Wha J., Bilow, Michael, Sul, Jae Hoon, Sankararaman, Sriram, Pasaniuc, Bogdan, Eskin, Eleazar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142122/
https://ncbi.nlm.nih.gov/pubmed/27866706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.10.003
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