Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx

BACKGROUND: Population structure among study subjects may confound genetic association studies, and lack of proper correction can lead to spurious findings. The Genotype-Tissue Expression (GTEx) project largely contains individuals of European ancestry, but the v8 release also includes up to 15% of...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Genome Biol
Main Authors: Gay, Nicole R., Gloudemans, Michael, Antonio, Margaret L., Abell, Nathan S., Balliu, Brunilda, Park, YoSon, Martin, Alicia R., Musharoff, Shaila, Rao, Abhiram S., Aguet, François, Barbeira, Alvaro N., Bonazzola, Rodrigo, Hormozdiari, Farhad, Ardlie, Kristin G., Brown, Christopher D., Im, Hae Kyung, Lappalainen, Tuuli, Wen, Xiaoquan, Montgomery, Stephen B.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488497/
https://ncbi.nlm.nih.gov/pubmed/32912333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02113-0
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