Colocalization of GWAS and eQTL Signals Detects Target Genes

The vast majority of genome-wide association study (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual’s disease risk through their effect on gene expression in different tissues. In order to understand the mechanisms d...

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Vydáno v:Am J Hum Genet
Hlavní autoři: Hormozdiari, Farhad, van de Bunt, Martijn, Segrè, Ayellet V., Li, Xiao, Joo, Jong Wha J., Bilow, Michael, Sul, Jae Hoon, Sankararaman, Sriram, Pasaniuc, Bogdan, Eskin, Eleazar
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142122/
https://ncbi.nlm.nih.gov/pubmed/27866706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.10.003
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