Structure‐Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi

Autor Sijm, Maarten, Sterk, Geert Jan, Caljon, Guy, Maes, Louis, de Esch, Iwan J. P., Leurs, Rob
Vydáno v ChemMedChem (2020)

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

Autor Sijm, Maarten, Maes, Louis, de Esch, Iwan J. P., Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Vydáno v Front Chem (2021)

Structural Analysis of Chemokine Receptor–Ligand Interactions

Autor Arimont, Marta, Sun, Shan-Liang, Leurs, Rob, Smit, Martine, de Esch, Iwan J. P., de Graaf, Chris
Vydáno v J Med Chem (2017)

KLIFS: an overhaul after the first 5 years of supporting kinase research

Autor Kanev, Georgi K, de Graaf, Chris, Westerman, Bart A, de Esch, Iwan J P, Kooistra, Albert J
Vydáno v Nucleic Acids Res (2020)

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs

Autor Stadel, Rebecca, Carpenter, Amanda B., Nalwalk, Julia W., de Esch, Iwan J.P., Janssen, Elwin, Hough, Lindsay B.
Vydáno 2010

Function-specific virtual screening for GPCR ligands using a combined scoring method

Autor Kooistra, Albert J., Vischer, Henry F., McNaught-Flores, Daniel, Leurs, Rob, de Esch, Iwan J. P., de Graaf, Chris
Vydáno v Sci Rep (2016)

Targeted LC–MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

Autor Eggink, Mark, Wijtmans, Maikel, Kretschmer, Ansgar, Kool, Jeroen, Lingeman, Henk, de Esch, Iwan J. P., Niessen, Wilfried M. A., Irth, Hubertus
Vydáno 2010

Diazepam-bound GABA(A) receptor models identify new benzodiazepine binding-site ligands

Autor Richter, Lars, de Graaf, Chris, Sieghart, Werner, Varagic, Zdravko, Mörzinger, Martina, de Esch, Iwan J P, Ecker, Gerhard F, Ernst, Margot
Vydáno 2012

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors

Autor Thompson, Andrew J., Verheij, Mark H.P., Verbeek, Joost, Windhorst, Albert D., de Esch, Iwan J.P., Lummis, Sarah C.R.
Vydáno v Neuropharmacology (2014)

KLIFS: a structural kinase-ligand interaction database

Autor Kooistra, Albert J., Kanev, Georgi K., van Linden, Oscar P.J., Leurs, Rob, de Esch, Iwan J.P., de Graaf, Chris
Vydáno v Nucleic Acids Res (2016)

A fluorescent approach for identifying P2X1 ligands

Autor Ruepp, Marc-David, Brozik, James A., de Esch, Iwan J.P., Farndale, Richard W., Murrell-Lagnado, Ruth D., Thompson, Andrew J.
Vydáno v Neuropharmacology (2015)

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

Autor Akdemir, Atilla, Edink, Ewald, Thompson, Andrew J., Lummis, Sarah C.R., Kooistra, Albert J., de Graaf, Chris, de Esch, Iwan J.P.
Vydáno 2012

3D‐e‐Chem: Structural Cheminformatics Workflows for Computer‐Aided Drug Discovery

Autor Kooistra, Albert J., Vass, Márton, McGuire, Ross, Leurs, Rob, de Esch, Iwan J. P., Vriend, Gert, Verhoeven, Stefan, de Graaf, Chris
Vydáno v ChemMedChem (2018)

Design, Synthesis, and Structure–Activity Relationships of Highly Potent 5-HT(3) Receptor Ligands

Autor Verheij, Mark H. P., Thompson, Andrew J., van Muijlwijk-Koezen, Jacqueline E., Lummis, Sarah C. R., Leurs, Rob, de Esch, Iwan J. P.
Vydáno 2012

Structure–Activity Relationships of Quinoxaline-Based 5-HT(3)A and 5-HT(3)AB Receptor-Selective Ligands

Autor Thompson, Andrew J, Verheij, Mark H P, van Muijlwijk-Koezen, Jacqueline E, Lummis, Sarah C R, Leurs, Rob, de Esch, Iwan J P
Vydáno 2013

Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics

Autor Wang, Zhiyong, Bosma, Reggie, Kuhne, Sebastiaan, van den Bor, Jelle, Garabitian, Wrej, Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.
Vydáno v ACS Omega (2021)

EPHA4 is overexpressed but not functionally active in Sézary syndrome

Autor Hameetman, Liesbeth, van der Fits, Leslie, Zoutman, Willem H., Out-Luiting, Jacoba J., Siegal, Gregg, de Esch, Iwan J.P., Vermeer, Maarten H., Tensen, Cornelis P.
Vydáno v Oncotarget (2015)

Bromo-Cyclobutenaminones as New Covalent UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Autor Hamilton, David J., Ábrányi-Balogh, Péter, Keeley, Aaron, Petri, László, Hrast, Martina, Imre, Tímea, Wijtmans, Maikel, Gobec, Stanislav, de Esch, Iwan J. P., Keserű, György Miklós
Vydáno v Pharmaceuticals (Basel) (2020)

CC12, A High Affinity Ligand for (3)H-Cimetidine Binding, is an Improgan Antagonist

Autor Hough, Lindsay B., Nalwalk, Julia W., Phillips, James G., Kern, Brian, Shan, Zhixing, Wentland, Mark P., de Esch, Iwan J.P., Janssen, Elwin, Barr, Travis, Stadel, Rebecca
Vydáno 2007

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure

Autor Jansen, Chimed, Wang, Huanchen, Kooistra, Albert J., de Graaf, Chris, Orrling, Kristina, Tenor, Hermann, Seebeck, Thomas, Bailey, David, de Esch, Iwan J.P., Ke, Hengming, Leurs, Rob
Vydáno 2013