The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors

VUF10166 (2-chloro-3-(4-methyl piperazin-1-yl)quinoxaline) is a ligand that binds with high affinity to 5-HT(3) receptors. Here we synthesise [(3)H]VUF10166 and characterise its binding properties at 5-HT(3)A and 5-HT(3)AB receptors. At 5-HT(3)A receptors [(3)H]VUF10166 displayed saturable binding w...

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Bibliographic Details
Published in:Neuropharmacology
Main Authors: Thompson, Andrew J., Verheij, Mark H.P., Verbeek, Joost, Windhorst, Albert D., de Esch, Iwan J.P., Lummis, Sarah C.R.
Format: Artigo
Language:Inglês
Published: Pergamon Press 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4220016/
https://ncbi.nlm.nih.gov/pubmed/25174552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.08.008
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