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Agonists and antagonists induce different palonosetron dissociation rates in 5-HT(3)A and 5-HT(3)AB receptors()

Palonosetron is a potent 5-HT(3) receptor antagonist with a unique structure and some unusual properties. Here we explore the properties of palonosetron at heterologously expressed 5-HT(3)A and 5-HT(3)AB receptors. We used receptors expressed in HEK293 cells, and functionally analysed them using a m...

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Hlavní autoři: Lummis, Sarah C.R., Thompson, Andrew J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Pergamon Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778450/
https://ncbi.nlm.nih.gov/pubmed/23747573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.05.010
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