The European Lead Factory: A Blueprint for Public–Private Partnerships in Early Drug Discovery

Por Karawajczyk, Anna, Orrling, Kristina M., de Vlieger, Jon S. B., Rijnders, Ton, Tzalis, Dimitrios
Publicado no Front Med (Lausanne) (2017)

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure

Por Jansen, Chimed, Wang, Huanchen, Kooistra, Albert J., de Graaf, Chris, Orrling, Kristina, Tenor, Hermann, Seebeck, Thomas, Bailey, David, de Esch, Iwan J.P., Ke, Hengming, Leurs, Rob
Publicado em 2013

Simple Colorimetric Trypanothione Reductase-Based Assay for High-Throughput Screening of Drugs against Leishmania Intracellular Amastigotes

Por van den Bogaart, Erika, Schoone, Gerard J., England, Paul, Faber, Dorien, Orrling, Kristina M., Dujardin, Jean-Claude, Sundar, Shyam, Schallig, Henk D. F. H., Adams, Emily R.
Publicado em 2014

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Por Blaazer, Antoni R., Singh, Abhimanyu K., de Heuvel, Erik, Edink, Ewald, Orrling, Kristina M., Veerman, Johan J. N., van den Bergh, Toine, Jansen, Chimed, Balasubramaniam, Erin, Mooij, Wouter J., Custers, Hans, Sijm, Maarten, Tagoe, Daniel N. A., Kalejaiye, Titilola D., Munday, Jane C., Tenor, Hermann, Matheeussen, An, Wijtmans, Maikel, Siderius, Marco, de Graaf, Chris, Maes, Louis, de Koning, Harry P., Bailey, David S., Sterk, Geert Jan, de Esch, Iwan J. P., Brown, David G., Leurs, Rob
Publicado no J Med Chem (2018)