Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

по Drewry, David H., Willson, Timothy M., Zuercher, William J.
Опубликовано в: Curr Top Med Chem (2014)

Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element

по Arao, Yukitomo, Coons, Laurel A., Zuercher, William J., Korach, Kenneth S.
Опубликовано в: J Biol Chem (2015)

Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor

по Zhang, Cunyu, Creech, Katrina L., Zuercher, William J., Willson, Timothy M.
Опубликовано в: Sci Rep (2019)

A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction

по Drewry, David H., Wells, Carrow I., Zuercher, William J., Willson, Timothy M.
Опубликовано в: SLAS Discov (2019)

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

по Asquith, Christopher R. M., Laitinen, Tuomo, Wells, Carrow I., Tizzard, Graham J., Zuercher, William J.
Опубликовано в: Molecules (2020)

Crystal Structure of the PXR-T1317 Complex Provides a Scaffold to Examine the Potential for Receptor Antagonism

по Xue, Yu, Chao, Esther, Zuercher, William J., Willson, Timothy M., Collins, Jon L., Redinbo, Matthew R.
Опубликовано 2006

The metabolic regulator ERRα, a downstream target of HER2/IGF-1, as a therapeutic target in breast cancer

по Chang, Ching-yi, Kazmin, Dmitri, Jasper, Jeff S., Kunder, Rebecca, Zuercher, William J., McDonnell, Donald P.
Опубликовано 2011

Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

по Dranchak, Patricia, MacArthur, Ryan, Guha, Rajarshi, Zuercher, William J., Drewry, David H., Auld, Douglas S., Inglese, James
Опубликовано 2013

Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines

по Asquith, Christopher R. M., Fleck, Neil, Torrice, Chad D., Crona, Daniel J., Grundner, Christoph, Zuercher, William J.
Опубликовано в: Bioorg Med Chem Lett (2019)

Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling

по Herneisen, Alice L., Sidik, Saima M., Markus, Benedikt M., Drewry, David H., Zuercher, William J., Lourido, Sebastian
Опубликовано в: ACS Chem Biol (2020)

High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-tran...

по Khan, Amina S, Murray, Matthew J, Ho, Catherine M. K, Zuercher, William J, Reeves, Matthew B, Strang, Blair L
Опубликовано в: J Gen Virol (2017)

Nuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community

по Lanz, Rainer B., Jericevic, Zeljko, Zuercher, William J., Watkins, Chris, Steffen, David L., Margolis, Ronald, McKenna, Neil J.
Опубликовано 2006

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA

по Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Striker, Rob, Sauer, John-Demian
Опубликовано в: J Biol Chem (2017)

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

по Wang, Christopher B., Lorente-Macías, Álvaro, Wells, Carrow, Pickett, Julie E., Picado, Alfredo, Zuercher, William J., Axtman, Alison D.
Опубликовано в: RSC Med Chem (2020)

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data

по Strang, Blair L., Asquith, Christopher R. M., Moshrif, Hanan F., Ho, Catherine M-K, Zuercher, William J., Al-Ali, Hassan
Опубликовано в: PLoS One (2018)

GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus

по Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Ferrer, Carla A., Sauer, John-Demian, Striker, Rob
Опубликовано в: ACS Infect Dis (2018)

Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

по Volpatti, Jonathan R, Endo, Yukari, Knox, Jessica, Groom, Linda, Brennan, Stephanie, Noche, Ramil, Zuercher, William J, Roy, Peter, Dirksen, Robert T, Dowling, James J
Опубликовано в: eLife (2020)

Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes

по Miao, Ji, Choi, Sung-E, Seok, Sun Mi, Yang, Linda, Zuercher, William J., Xu, Yong, Willson, Timothy M., Xu, H. Eric, Kemper, Jongsook Kim
Опубликовано 2011

On the intractability of estrogen-related receptor α as a target for activation by small molecules

по Hyatt, Stephen M., Lockamy, Elizabeth, Stein, Rebecca A., McDonnell, Donald P., Miller, Aaron B., Orband-Miller, Lisa A., Willson, Timothy M., Zuercher, William J.
Опубликовано 2007

Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

по Carabajal, María Ayelén, Asquith, Christopher R. M., Laitinen, Tuomo, Tizzard, Graham J., Yim, Lucía, Rial, Analía, Chabalgoity, José A., Zuercher, William J., García Véscovi, Eleonora
Опубликовано в: Antimicrob Agents Chemother (2019)