Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

بواسطة Drewry, David H., Willson, Timothy M., Zuercher, William J.
الحاوية / القاعدة Curr Top Med Chem (2014)

Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element

بواسطة Arao, Yukitomo, Coons, Laurel A., Zuercher, William J., Korach, Kenneth S.
الحاوية / القاعدة J Biol Chem (2015)

Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor

بواسطة Zhang, Cunyu, Creech, Katrina L., Zuercher, William J., Willson, Timothy M.
الحاوية / القاعدة Sci Rep (2019)

A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction

بواسطة Drewry, David H., Wells, Carrow I., Zuercher, William J., Willson, Timothy M.
الحاوية / القاعدة SLAS Discov (2019)

New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)

بواسطة Asquith, Christopher R. M., Laitinen, Tuomo, Wells, Carrow I., Tizzard, Graham J., Zuercher, William J.
الحاوية / القاعدة Molecules (2020)

Crystal Structure of the PXR-T1317 Complex Provides a Scaffold to Examine the Potential for Receptor Antagonism

بواسطة Xue, Yu, Chao, Esther, Zuercher, William J., Willson, Timothy M., Collins, Jon L., Redinbo, Matthew R.
منشور في 2006

The metabolic regulator ERRα, a downstream target of HER2/IGF-1, as a therapeutic target in breast cancer

بواسطة Chang, Ching-yi, Kazmin, Dmitri, Jasper, Jeff S., Kunder, Rebecca, Zuercher, William J., McDonnell, Donald P.
منشور في 2011

Profile of the GSK Published Protein Kinase Inhibitor Set Across ATP-Dependent and-Independent Luciferases: Implications for Reporter-Gene Assays

بواسطة Dranchak, Patricia, MacArthur, Ryan, Guha, Rajarshi, Zuercher, William J., Drewry, David H., Auld, Douglas S., Inglese, James
منشور في 2013

Anti-tubercular activity of novel 4-anilinoquinolines and 4-anilinoquinazolines

بواسطة Asquith, Christopher R. M., Fleck, Neil, Torrice, Chad D., Crona, Daniel J., Grundner, Christoph, Zuercher, William J.
الحاوية / القاعدة Bioorg Med Chem Lett (2019)

Identifying the target of an antiparasitic compound in Toxoplasma using thermal proteome profiling

بواسطة Herneisen, Alice L., Sidik, Saima M., Markus, Benedikt M., Drewry, David H., Zuercher, William J., Lourido, Sebastian
الحاوية / القاعدة ACS Chem Biol (2020)

High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-tran...

بواسطة Khan, Amina S, Murray, Matthew J, Ho, Catherine M. K, Zuercher, William J, Reeves, Matthew B, Strang, Blair L
الحاوية / القاعدة J Gen Virol (2017)

Nuclear Receptor Signaling Atlas (): hyperlinking the nuclear receptor signaling community

بواسطة Lanz, Rainer B., Jericevic, Zeljko, Zuercher, William J., Watkins, Chris, Steffen, David L., Margolis, Ronald, McKenna, Neil J.
منشور في 2006

A screen for kinase inhibitors identifies antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes PASTA kinase PrkA

بواسطة Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Striker, Rob, Sauer, John-Demian
الحاوية / القاعدة J Biol Chem (2017)

Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series

بواسطة Wang, Christopher B., Lorente-Macías, Álvaro, Wells, Carrow, Pickett, Julie E., Picado, Alfredo, Zuercher, William J., Axtman, Alison D.
الحاوية / القاعدة RSC Med Chem (2020)

Identification of lead anti-human cytomegalovirus compounds targeting MAP4K4 via machine learning analysis of kinase inhibitor screening data

بواسطة Strang, Blair L., Asquith, Christopher R. M., Moshrif, Hanan F., Ho, Catherine M-K, Zuercher, William J., Al-Ali, Hassan
الحاوية / القاعدة PLoS One (2018)

GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus

بواسطة Schaenzer, Adam J., Wlodarchak, Nathan, Drewry, David H., Zuercher, William J., Rose, Warren E., Ferrer, Carla A., Sauer, John-Demian, Striker, Rob
الحاوية / القاعدة ACS Infect Dis (2018)

Identification of drug modifiers for RYR1-related myopathy using a multi-species discovery pipeline

بواسطة Volpatti, Jonathan R, Endo, Yukari, Knox, Jessica, Groom, Linda, Brennan, Stephanie, Noche, Ramil, Zuercher, William J, Roy, Peter, Dirksen, Robert T, Dowling, James J
الحاوية / القاعدة eLife (2020)

Ligand-Dependent Regulation of the Activity of the Orphan Nuclear Receptor, Small Heterodimer Partner (SHP), in the Repression of Bile Acid Biosynthetic CYP7A1 and CYP8B1 Genes

بواسطة Miao, Ji, Choi, Sung-E, Seok, Sun Mi, Yang, Linda, Zuercher, William J., Xu, Yong, Willson, Timothy M., Xu, H. Eric, Kemper, Jongsook Kim
منشور في 2011

On the intractability of estrogen-related receptor α as a target for activation by small molecules

بواسطة Hyatt, Stephen M., Lockamy, Elizabeth, Stein, Rebecca A., McDonnell, Donald P., Miller, Aaron B., Orband-Miller, Lisa A., Willson, Timothy M., Zuercher, William J.
منشور في 2007

Quinazoline-Based Antivirulence Compounds Selectively Target Salmonella PhoP/PhoQ Signal Transduction System

بواسطة Carabajal, María Ayelén, Asquith, Christopher R. M., Laitinen, Tuomo, Tizzard, Graham J., Yim, Lucía, Rial, Analía, Chabalgoity, José A., Zuercher, William J., García Véscovi, Eleonora
الحاوية / القاعدة Antimicrob Agents Chemother (2019)