Design and Synthesis of 2,6-Disubstituted-4′-Selenoadenosine-5′-N,N-Dimethyluronamide Derivatives as Human A(3) Adenosine Receptor Antagonists

por Choi, Hongseok, Jacobson, Kenneth A., Yu, Jinha, Jeong, Lak Shin
Publicado en Pharmaceuticals (Basel) (2021)

Structure-Guided Modification of Heterocyclic Antagonists of the P2Y(14) Receptor

por Yu, Jinha, Ciancetta, Antonella, Dudas, Steven, Duca, Sierra, Lottermoser, Justine, Jacobson, Kenneth A.
Publicado en J Med Chem (2018)

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice

por Park, Jong-Gil, Jeongs, Se-Jin, Yu, Jinha, Kim, Gyudong, Jeong, Lak Shin, Oh, Goo Taeg
Publicado en BMB Rep (2018)

Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

por Sahu, Pramod K., Umme, Tamima, Yu, Jinha, Kim, Gyudong, Qu, Shuhao, Naik, Siddhi D., Jeong, Lak Shin
Publicado en Molecules (2017)

P2Y(14) Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

por Mufti, Fatma, Jung, Young-Hwan, Giancotti, Luigino Antonio, Yu, Jinha, Chen, Zhoumou, Phung, Ngan B., Jacobson, Kenneth A., Salvemini, Daniela
Publicado en ACS Med Chem Lett (2020)

Bitopic fluorescent antagonists of the A(2A) adenosine receptor based on pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine functionalized congeners

por Duroux, Romain, Ciancetta, Antonella, Mannes, Philip, Yu, Jinha, Boyapati, Shireesha, Gizewski, Elizabeth, Yous, Said, Ciruela, Francisco, Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado en Medchemcomm (2017)

Structure activity relationship of 2-arylalkynyl-adenine derivatives as human A(3) adenosine receptor antagonists

por Yu, Jinha, Mannes, Philip, Jung, Young-Hwan, Ciancetta, Antonella, Bitant, Amelia, Lieberman, David I., Khaznadar, Sami, Auchampach, John A., Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado en Medchemcomm (2018)

Radiosensitization by the investigational NEDD8-activating enzyme inhibitor MLN4924 (pevonedistat) in hormone-resistant prostate cancer cells

por Wang, Xiaofang, Zhang, Wenjuan, Yan, Zi, Liang, Yupei, Li, Lihui, Yu, Xiaoli, Feng, Yan, Fu, Shen, Zhang, Yanmei, Zhao, Hu, Yu, Jinha, Jeong, Lak Shin, Guo, Xiaomao, Jia, Lijun
Publicado en Oncotarget (2016)

A Cannabinoid Receptor Agonist N-Arachidonoyl Dopamine Inhibits Adipocyte Differentiation in Human Mesenchymal Stem Cells

por Ahn, Seyeon, Yi, Sodam, Seo, Won Jong, Lee, Myeong Jung, Song, Young Keun, Baek, Seung Yong, Yu, Jinha, Hong, Soo Hyun, Lee, Jinyoung, Shin, Dong Wook, Jeong, Lak Shin, Noh, Minsoo
Publicado en Biomol Ther (Seoul) (2015)

Polypharmacology of N(6)-(3-Iodobenzyl)adenosine-5′-N-methyluronamide (IB-MECA) and Related A(3) Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Par...

por Yu, Jinha, Ahn, Seyeon, Kim, Hee Jin, Lee, Moonyoung, Ahn, Sungjin, Kim, Jungmin, Jin, Sun Hee, Lee, Eunyoung, Kim, Gyudong, Cheong, Jae Hoon, Jacobson, Kenneth A., Jeong, Lak Shin, Noh, Minsoo
Publicado en J Med Chem (2017)

Exploration of Alternative Scaffolds for P2Y(14) Receptor Antagonists Containing a Biaryl Core

por Jung, Young-Hwan, Yu, Jinha, Wen, Zhiwei, Salmaso, Veronica, Karcz, Tadeusz P., Phung, Ngan B., Chen, Zhoumou, Duca, Sierra, Bennett, John M., Dudas, Steven, Salvemini, Daniela, Gao, Zhan-Guo, Cook, Donald N., Jacobson, Kenneth A.
Publicado en J Med Chem (2020)

The Nedd8‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma

por Zhang, Wenjuan, Liang, Yupei, Li, Lihui, Wang, Xiaofang, Yan, Zi, Dong, Changsheng, Zeng, Mu‐Sheng, Zhong, Qian, Liu, Xue‐Kui, Yu, Jinha, Sun, Shuyang, Liu, Xiaojun, Kang, Jihui, Zhao, Hu, Jeong, Lak Shin, Zhang, Yanmei, Jia, Lijun
Publicado en Cell Prolif (2018)

N(6)-Substituted-5′-N-Methylcarbamoyl-4′-selenoadenosines as Potent and Selective A(3) Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation

por Yu, Jinha, Zhao, Long Xuan, Park, Jongmi, Lee, Hyuk Woo, Sahu, Pramod K., Cui, Minghua, Moss, Steven M., Hammes, Eva, Warnick, Eugene, Gao, Zhan-Guo, Noh, Minsoo, Choi, Sun, Ahn, Hee-Chul, Choi, Jungwon, Jacobson, Kenneth A., Jeong, Lak Shin
Publicado en J Med Chem (2017)

Discovery and Structure–Activity Relationships of Novel Template, Truncated 1′-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators

por An, Seungchan, Kim, Gyudong, Jin Kim, Hyun, Ahn, Sungjin, Kim, Hyun Young, Ko, Hyejin, Hyun, Young Eum, Nguyen, Mai, Jeong, Juri, Liu, Zijing, Han, Jinhe, Choi, Hongseok, Yu, Jinha, Kim, Ji Won, Lee, Hyuk Woo, Jacobson, Kenneth A., Cho, Won Jea, Kim, Young-Mi, Kang, Keon Wook, Noh, Minsoo, Jeong, Lak Shin
Publicado en J Med Chem (2020)