Exploration of Alternative Scaffolds for P2Y(14) Receptor Antagonists Containing a Biaryl Core

Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y(14) receptor (P2Y(14)R) antagonists were synthesized, and affinity was measured in P2Y(14)R-expressing Chinese hamster ovary cells by flow cytometry. Given this series’ low water solubility, various polyethylene glycol der...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Jung, Young-Hwan, Yu, Jinha, Wen, Zhiwei, Salmaso, Veronica, Karcz, Tadeusz P., Phung, Ngan B., Chen, Zhoumou, Duca, Sierra, Bennett, John M., Dudas, Steven, Salvemini, Daniela, Gao, Zhan-Guo, Cook, Donald N., Jacobson, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040948/
https://ncbi.nlm.nih.gov/pubmed/32787142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00745
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