Discovery and Structure–Activity Relationships of Novel Template, Truncated 1′-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators

Following our report that A(3) adenosine receptor (AR) antagonist 1 exhibited a polypharmacological profile as a dual modulator of peroxisome proliferator-activated receptor (PPAR)γ/δ, we discovered a new template, 1′-homologated adenosine analogues 4a–4t, as dual PPARγ/δ modulators without AR bindi...

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Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: An, Seungchan, Kim, Gyudong, Jin Kim, Hyun, Ahn, Sungjin, Kim, Hyun Young, Ko, Hyejin, Hyun, Young Eum, Nguyen, Mai, Jeong, Juri, Liu, Zijing, Han, Jinhe, Choi, Hongseok, Yu, Jinha, Kim, Ji Won, Lee, Hyuk Woo, Jacobson, Kenneth A., Cho, Won Jea, Kim, Young-Mi, Kang, Keon Wook, Noh, Minsoo, Jeong, Lak Shin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201645/
https://ncbi.nlm.nih.gov/pubmed/33325691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01874
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