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Polypharmacology of N(6)-(3-Iodobenzyl)adenosine-5′-N-methyluronamide (IB-MECA) and Related A(3) Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential

A(3) adenosine receptor (AR) ligands including A(3) AR agonist, N(6)-(3-iodobenzyl)adenosine-5′-N-methyluronamide (1a, IB-MECA) were examined for adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs). In this model, 1a significantly increased adiponectin production, which is...

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Vydáno v:J Med Chem
Hlavní autoři: Yu, Jinha, Ahn, Seyeon, Kim, Hee Jin, Lee, Moonyoung, Ahn, Sungjin, Kim, Jungmin, Jin, Sun Hee, Lee, Eunyoung, Kim, Gyudong, Cheong, Jae Hoon, Jacobson, Kenneth A., Jeong, Lak Shin, Noh, Minsoo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5956890/
https://ncbi.nlm.nih.gov/pubmed/28799755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00805
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