N(6)-Substituted-5′-N-Methylcarbamoyl-4′-selenoadenosines as Potent and Selective A(3) Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation

Potent and selective A(3) adenosine receptor (AR) agonists were identified by replacement of 4′-oxo- or 4′-thionucleosides with bioisosteric selenium. Unlike previous agonists, 4′-seleno analogues preferred a glycosidic syn conformation and a South sugar puckering, as shown in the X-ray crystal stru...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Yu, Jinha, Zhao, Long Xuan, Park, Jongmi, Lee, Hyuk Woo, Sahu, Pramod K., Cui, Minghua, Moss, Steven M., Hammes, Eva, Warnick, Eugene, Gao, Zhan-Guo, Noh, Minsoo, Choi, Sun, Ahn, Hee-Chul, Choi, Jungwon, Jacobson, Kenneth A., Jeong, Lak Shin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5479327/
https://ncbi.nlm.nih.gov/pubmed/28380296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00241
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