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N(6)-Substituted-5′-N-Methylcarbamoyl-4′-selenoadenosines as Potent and Selective A(3) Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation
Potent and selective A(3) adenosine receptor (AR) agonists were identified by replacement of 4′-oxo- or 4′-thionucleosides with bioisosteric selenium. Unlike previous agonists, 4′-seleno analogues preferred a glycosidic syn conformation and a South sugar puckering, as shown in the X-ray crystal stru...
Gorde:
| Argitaratua izan da: | J Med Chem |
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| Egile Nagusiak: | , , , , , , , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5479327/ https://ncbi.nlm.nih.gov/pubmed/28380296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00241 |
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