Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer

Modified thrombin-binding aptamers carrying 2′-deoxyguanine (dG) residues with locked North- or South-bicyclo[3.1.0]hexane pseudosugars were synthesized. Individual 2′-deoxyguanosines at positions dG5, dG10, dG14 and dG15 of the aptamer were replaced by these analogues where the North/anti and South...

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Detalhes bibliográficos
Main Authors: Saneyoshi, Hisao, Mazzini, Stefania, Aviñó, Anna, Portella, Guillem, González, Carlos, Orozco, Modesto, Marquez, Víctor E., Eritja, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Chemistry and Synthetic Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761269/
https://ncbi.nlm.nih.gov/pubmed/19620215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp598
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