Discovery and Structure–Activity Relationships of Novel Template, Truncated 1′-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators

Following our report that A(3) adenosine receptor (AR) antagonist 1 exhibited a polypharmacological profile as a dual modulator of peroxisome proliferator-activated receptor (PPAR)γ/δ, we discovered a new template, 1′-homologated adenosine analogues 4a–4t, as dual PPARγ/δ modulators without AR bindi...

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Publicado en:J Med Chem
Main Authors: An, Seungchan, Kim, Gyudong, Jin Kim, Hyun, Ahn, Sungjin, Kim, Hyun Young, Ko, Hyejin, Hyun, Young Eum, Nguyen, Mai, Jeong, Juri, Liu, Zijing, Han, Jinhe, Choi, Hongseok, Yu, Jinha, Kim, Ji Won, Lee, Hyuk Woo, Jacobson, Kenneth A., Cho, Won Jea, Kim, Young-Mi, Kang, Keon Wook, Noh, Minsoo, Jeong, Lak Shin
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201645/
https://ncbi.nlm.nih.gov/pubmed/33325691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01874
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