The Nedd8‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma

OBJECTIVES: The present study aimed to reveal expression status of the neddylation enzymes in HNSCC and to elucidate the anticancer efficacy and the underlying mechanisms of inhibiting neddylation pathway. MATERIALS AND METHODS: The expression levels of neddylation enzymes were estimated by Western...

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Detalhes bibliográficos
Publicado no:Cell Prolif
Main Authors: Zhang, Wenjuan, Liang, Yupei, Li, Lihui, Wang, Xiaofang, Yan, Zi, Dong, Changsheng, Zeng, Mu‐Sheng, Zhong, Qian, Liu, Xue‐Kui, Yu, Jinha, Sun, Shuyang, Liu, Xiaojun, Kang, Jihui, Zhao, Hu, Jeong, Lak Shin, Zhang, Yanmei, Jia, Lijun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496207/
https://ncbi.nlm.nih.gov/pubmed/30341788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12536
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