The Nedd8‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma

OBJECTIVES: The present study aimed to reveal expression status of the neddylation enzymes in HNSCC and to elucidate the anticancer efficacy and the underlying mechanisms of inhibiting neddylation pathway. MATERIALS AND METHODS: The expression levels of neddylation enzymes were estimated by Western...

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Bibliografiska uppgifter
I publikationen:Cell Prolif
Huvudupphovsmän: Zhang, Wenjuan, Liang, Yupei, Li, Lihui, Wang, Xiaofang, Yan, Zi, Dong, Changsheng, Zeng, Mu‐Sheng, Zhong, Qian, Liu, Xue‐Kui, Yu, Jinha, Sun, Shuyang, Liu, Xiaojun, Kang, Jihui, Zhao, Hu, Jeong, Lak Shin, Zhang, Yanmei, Jia, Lijun
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496207/
https://ncbi.nlm.nih.gov/pubmed/30341788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12536
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