Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase

Por Yoshimoto, Francis K., Guengerich, F. Peter
Publicado em 2014

The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)

Por Yoshimoto, Francis K., Auchus, Richard J.
Publicado no J Steroid Biochem Mol Biol (2014)

Rapid kinetic methods to dissect steroidogenic cytochrome P450 reaction mechanisms

Por Yoshimoto, Francis K., Auchus, Richard J.
Publicado no J Steroid Biochem Mol Biol (2015)

Synthesis of halogenated pregnanes, mechanistic probes of steroid hydroxylases CYP17A1 and CYP21A2

Por Yoshimoto, Francis K., Desilets, Melissa C., Auchus, Richard J.
Publicado em 2011

Pt-Catalyzed Pentannulations from In Situ Generated Metallo–Carbenoids Utilizing Propargylic Esters

Por Bhanu Prasad, B. A., Yoshimoto, Francis K., Sarpong, Richmond
Publicado em 2005

Oxidation of Dihydrotestosterone by Human Cytochromes P450 19A1 and 3A4

Por Cheng, Qian, Sohl, Christal D., Yoshimoto, Francis K., Guengerich, F. Peter
Publicado em 2012

Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: (18)O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN

Por Yoshimoto, Francis K., Gonzalez, Eric, Auchus, Richard J., Guengerich, F. Peter
Publicado no J Biol Chem (2016)

Mechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1. (18)O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.

Por Yoshimoto, Francis K., Gonzalez, Eric, Auchus, Richard J., Guengerich, F. Peter
Publicado no J Biol Chem (2016)

A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid

Por Bender, Christopher F., Yoshimoto, Francis K., Paradise, Christopher L., De Brabander, Jef K.
Publicado em 2009

Isotope-Labeling Studies Support an Electrophilic Compound I Iron Active Species (FeO(3+)) for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side Chain Cleavage Enzym...

Por Yoshimoto, Francis K., Jung, I-Ji, Goyal, Sandeep, Gonzalez, Eric, Guengerich, F. Peter
Publicado no J Am Chem Soc (2016)

Oxidation of Endogenous N-Arachidonoylserotonin by Human Cytochrome P450 2U1

Por Siller, Michal, Goyal, Sandeep, Yoshimoto, Francis K., Xiao, Yi, Wei, Shouzou, Guengerich, F. Peter
Publicado em 2014

Epoxidation Activities of Human Cytochromes P450c17 and P450c21

Por Yoshimoto, Francis K., Peng, Hwei-Ming, Zhang, Haoming, Anderson, Sean M., Auchus, Richard J.
Publicado no Biochemistry (2014)

Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor

Por Tian, Zhenghua, Cheng, Qian, Yoshimoto, Francis K., Lei, Li, Lamb, David C., Guengerich, F. Peter
Publicado em 2013

A-Ring modified steroidal azoles retaining similar potent and slowly reversible CYP17A1 inhibition as abiraterone

Por Garrido, Mariana, Peng, Hwei-Ming, Yoshimoto, Francis K., Upadhyay, Sunil K., Bratoeff, Eugene, Auchus, Richard J.
Publicado no J Steroid Biochem Mol Biol (2014)

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia

Por Wang, Chunxue, Pallan, Pradeep S., Zhang, Wei, Lei, Li, Yoshimoto, Francis K., Waterman, Michael R., Egli, Martin, Guengerich, F. Peter
Publicado no J Biol Chem (2017)

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C–H BOND CLEAVAGE

Por Pallan, Pradeep S., Wang, Chunxue, Lei, Li, Yoshimoto, Francis K., Auchus, Richard J., Waterman, Michael R., Guengerich, F. Peter, Egli, Martin
Publicado no J Biol Chem (2015)

Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates

Por Yoshimoto, Francis K., Zhou, Yishan, Peng, Hwei-Ming, Stidd, David, Yoshimoto, Jennifer A., Sharma, Kamalesh K., Matthew, Susan, Auchus, Richard J.
Publicado em 2012

Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

Por Shimada, Tsutomu, Takenaka, Shigeo, Murayama, Norie, Yamazaki, Hiroshi, Kim, Joo-Hwan, Kim, Donghak, Yoshimoto, Francis K., Guengerich, F. Peter, Komori, Masayuki
Publicado no Chem Res Toxicol (2015)

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes

Por Gonzalez, Eric, Johnson, Kevin M., Pallan, Pradeep S., Phan, Thanh T. N., Zhang, Wei, Lei, Li, Wawrzak, Zdzislaw, Yoshimoto, Francis K., Egli, Martin, Guengerich, F. Peter
Publicado no J Biol Chem (2018)