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Mechanism of the Third Oxidative Step in the Conversion of Androgens to Estrogens by Cytochrome P450 19A1 Steroid Aromatase
[Image: see text] Aromatase is the cytochrome P450 enzyme that cleaves the C10–C19 carbon–carbon bond of androgens to form estrogens, in a three-step process. Compound I (FeO(3+)) and ferric peroxide (FeO(2)(–)) have both been proposed in the literature as the active iron species in the third step,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210144/ https://ncbi.nlm.nih.gov/pubmed/25252141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja508185d |
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