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Kinetic Analysis of the Three-step Steroid Aromatase Reaction of Human Cytochrome P450 19A1

Cytochrome P450 19A1 (P450 19A1), the aromatase, catalyzes the conversion of androgens to estrogens through a sequential three-step reaction, generating 19-hydroxy and 19-aldehyde intermediates en route to the product estrogen. A procedure for the heterologous expression and purification of P450 19A...

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Bibliografische gegevens
Hoofdauteurs: Sohl, Christal D., Guengerich, F. Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878537/
https://ncbi.nlm.nih.gov/pubmed/20385561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.123711
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