Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

Acenaphthene and acenaphthylene, two known environmental polycyclic aromatic hydrocarbon (PAH) pollutants, were incubated at 50 µM concentrations in a standard reaction mixture with human P450s 2A6, 2A13, 1B1, 1A2, 2C9, and 3A4 and the oxidation products were determined using HPLC and LC-MS. HPLC an...

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Bibliographic Details
Published in:Chem Res Toxicol
Main Authors: Shimada, Tsutomu, Takenaka, Shigeo, Murayama, Norie, Yamazaki, Hiroshi, Kim, Joo-Hwan, Kim, Donghak, Yoshimoto, Francis K., Guengerich, F. Peter, Komori, Masayuki
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755721/
https://ncbi.nlm.nih.gov/pubmed/25642975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500505y
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