Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

1. 2′-, 3′-, and 4′-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods. 2. CYP1B1.1 and 1B1.3 were highly active in demethylating 4′...

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Gepubliceerd in:Xenobiotica
Hoofdauteurs: Nagayoshi, Haruna, Murayama, Norie, Tsujino, Masaki, Takenaka, Shigeo, Katahira, Jun, Kim, Vitchan, Kim, Donghak, Komori, Masayuki, Yamazaki, Hiroshi, Guengerich, F. Peter, Shimada, Tsutomu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7881365/
https://ncbi.nlm.nih.gov/pubmed/32312164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2020.1759157
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