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Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes
1. 2′-, 3′-, and 4′-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods. 2. CYP1B1.1 and 1B1.3 were highly active in demethylating 4′...
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| Pubblicato in: | Xenobiotica |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7881365/ https://ncbi.nlm.nih.gov/pubmed/32312164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2020.1759157 |
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