Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

1. The roles of human cytochrome P450 (P450 or CYP) 2A6 in the oxidation of flavanone [(2R)- and (2S)-enantiomers] and flavone were studied in human liver microsomes and recombinant human P450 enzymes. 2. CYP2A6 was highly active in oxidizing flavanone to form flavone, 2´-hydroxy-, 4´-, and 6-hydrox...

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Detalhes bibliográficos
Publicado no:Xenobiotica
Main Authors: Nagayoshi, Haruna, Murayama, Norie, Kakimoto, Kensaku, Takenaka, Shigeo, Katahira, Jun, Lim, Young-Ran, Kim, Vitchan, Kim, Donghak, Yamazaki, Hiroshi, Komori, Masayuki, Guengerich, F. Peter, Shimada, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438780/
https://ncbi.nlm.nih.gov/pubmed/30048196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2018.1505064
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