Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl

2,5,2′,5′-Tetrachlorobiphenyl (TCB) induced type I binding spectra with cytochrome P450 (P450) 2A6 and 2A13, with K(s) values of 9.4 and 0.51 µM, respectively. However, CYP2A6 oxidized 2,5,2′,5′-TCB to form 4-hydroxylated products at a much higher rate (∼1.0 minute(−1)) than CYP2A13 (∼0.02 minute(−1...

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Pubblicato in:Drug Metab Dispos
Autori principali: Shimada, Tsutomu, Kakimoto, Kensaku, Takenaka, Shigeo, Koga, Nobuyuki, Uehara, Shotaro, Murayama, Norie, Yamazaki, Hiroshi, Kim, Donghak, Guengerich, F. Peter, Komori, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047209/
https://ncbi.nlm.nih.gov/pubmed/27625140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.072991
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