Oxidation of 1-Chloropyrene by Human CYP1 Family and CYP2A Subfamily Cytochrome P450 Enzymes: Catalytic Roles of Two CYP1B1 and Five CYP2A13 Allelic Variants

1. Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4, and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic two CYP...

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Publicado no:Xenobiotica
Main Authors: Shimada, Tsutomu, Murayama, Norie, Kakimoto, Kensaku, Takenaka, Shigeo, Lim, Young-Ran, Yeom, Sora, Kim, Donghak, Yamazaki, Hiroshi, Guengerich, F. Peter, Komori, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780263/
https://ncbi.nlm.nih.gov/pubmed/28648140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1347306
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