Oxidation of 1-Chloropyrene by Human CYP1 Family and CYP2A Subfamily Cytochrome P450 Enzymes: Catalytic Roles of Two CYP1B1 and Five CYP2A13 Allelic Variants

1. Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4, and 3A5. Catalytic differences in 1-chloropyrene oxidation by polymorphic two CYP...

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Enregistré dans:
Détails bibliographiques
Publié dans:Xenobiotica
Auteurs principaux: Shimada, Tsutomu, Murayama, Norie, Kakimoto, Kensaku, Takenaka, Shigeo, Lim, Young-Ran, Yeom, Sora, Kim, Donghak, Yamazaki, Hiroshi, Guengerich, F. Peter, Komori, Masayuki
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780263/
https://ncbi.nlm.nih.gov/pubmed/28648140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1347306
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