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Minor activities and transition state properties of the human steroid hydroxylases cytochromes P450c17 and P450c21, from reactions observed with deuterium-labeled substrates

The steroid hydroxylases CYP17A1 (P450c17, 17-hydroxylase/17,20-lyase) and CYP21A2 (P450c21, 21-hydroxylase) catalyze progesterone hydroxylation at one or more sites within a 2 Å radius. We probed their hydrogen atom abstraction mechanisms and regiochemical plasticity with deuterium-labeled substrat...

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Detalhes bibliográficos
Main Authors: Yoshimoto, Francis K., Zhou, Yishan, Peng, Hwei-Ming, Stidd, David, Yoshimoto, Jennifer A., Sharma, Kamalesh K., Matthew, Susan, Auchus, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471366/
https://ncbi.nlm.nih.gov/pubmed/22873692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300895w
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