Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

Por Hall, Belinda S., Wilkinson, Shane R.
Publicado em 2012

Nifurtimox Activation by Trypanosomal Type I Nitroreductases Generates Cytotoxic Nitrile Metabolites

Por Hall, Belinda S., Bot, Christopher, Wilkinson, Shane R.
Publicado em 2011

Targeting the Substrate Preference of a Type I Nitroreductase To Develop Antitrypanosomal Quinone-Based Prodrugs

Por Hall, Belinda S., Meredith, Emma Louise, Wilkinson, Shane R.
Publicado em 2012

Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

Por Hall, Belinda S., Wu, Xinghua, Hu, Longqin, Wilkinson, Shane R.
Publicado em 2010

Substoichiometric Levels of Cu(2+) Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

Por Sarell, Claire J., Wilkinson, Shane R., Viles, John H.
Publicado em 2010

Deletion of the Trypanosoma brucei Superoxide Dismutase Gene sodb1 Increases Sensitivity to Nifurtimox and Benznidazole

Por Prathalingham, S. Radhika, Wilkinson, Shane R., Horn, David, Kelly, John M.
Publicado em 2007

Evaluating Aziridinyl Nitrobenzamide Compounds as Leishmanicidal Prodrugs

Por Voak, Andrew A., Seifert, Karin, Helsby, Nuala A., Wilkinson, Shane R.
Publicado em 2014

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum

Por Wilkinson, Shane R., Obado, Samson O., Mauricio, Isabel L., Kelly, John M.
Publicado em 2002

Evaluating 5-Nitrothiazoles as Trypanocidal Agents

Por O'Shea, Ivan P., Shahed, Mohammed, Aguilera-Venegas, Benjamín, Wilkinson, Shane R.
Publicado no Antimicrob Agents Chemother (2016)

Vitamin C biosynthesis in trypanosomes: A role for the glycosome

Por Wilkinson, Shane R., Prathalingam, S. Radhika, Taylor, Martin C., Horn, David, Kelly, John M.
Publicado em 2005

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

Por Wilkinson, Shane R., Taylor, Martin C., Horn, David, Kelly, John M., Cheeseman, Ian
Publicado em 2008

Validation of spermidine synthase as a drug target in African trypanosomes

Por Taylor, Martin C., Kaur, Harparkash, Blessington, Bernard, Kelly, John M., Wilkinson, Shane R.
Publicado em 2008

The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase

Por Logan, Flora J., Taylor, Martin C., Wilkinson, Shane R., Kaur, Harparkash, Kelly, John M.
Publicado em 2007

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional “strand-switch” domain as a major feature

Por Obado, Samson O., Taylor, Martin C., Wilkinson, Shane R., Bromley, Elizabeth V., Kelly, John M.
Publicado em 2005

Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite

Por Piacenza, Lucía, Peluffo, Gonzalo, Alvarez, María Noel, Kelly, John M., Wilkinson, Shane R., Radi, Rafael
Publicado em 2008

Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs

Por Bot, Chris, Hall, Belinda S., Bashir, Noosheen, Taylor, Martin C., Helsby, Nuala A., Wilkinson, Shane R.
Publicado em 2010

The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence

Por Taylor, Martin C., Lewis, Michael D., Francisco, Amanda Fortes, Wilkinson, Shane R., Kelly, John M.
Publicado no PLoS Negl Trop Dis (2015)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

Por Papadopoulou, Maria V., Bloomer, William D., Rosenzweig, Howard S., Wilkinson, Shane R., Szular, Joanna, Kaiser, Marcel
Publicado no Eur J Med Chem (2016)

Evaluating 5-Nitrofurans as Trypanocidal Agents

Por Bot, Christopher, Hall, Belinda S., Álvarez, Guzmán, Di Maio, Rossanna, González, Mercedes, Cerecetto, Hugo, Wilkinson, Shane R.
Publicado em 2013