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Evaluating 5-Nitrofurans as Trypanocidal Agents

The nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targeting Trypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction c...

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Autori principali: Bot, Christopher, Hall, Belinda S., Álvarez, Guzmán, Di Maio, Rossanna, González, Mercedes, Cerecetto, Hugo, Wilkinson, Shane R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3623332/
https://ncbi.nlm.nih.gov/pubmed/23335745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02046-12
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