Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs

The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide de...

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Autors principals: Bot, Chris, Hall, Belinda S., Bashir, Noosheen, Taylor, Martin C., Helsby, Nuala A., Wilkinson, Shane R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Susceptibility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944584/
https://ncbi.nlm.nih.gov/pubmed/20679506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00800-10
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