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Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs
Quinone‐based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4‐benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutan...
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| Pubblicato in: | Mol Microbiol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5656836/ https://ncbi.nlm.nih.gov/pubmed/28792090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13767 |
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