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Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs
Quinone‐based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4‐benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutan...
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| Publicado no: | Mol Microbiol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5656836/ https://ncbi.nlm.nih.gov/pubmed/28792090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13767 |
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