Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

Quinone‐based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4‐benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutan...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Microbiol
Egile Nagusiak: Meredith, Emma Louise, Kumar, Ambika, Konno, Aya, Szular, Joanna, Alsford, Sam, Seifert, Karin, Horn, David, Wilkinson, Shane R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2017
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656836/
https://ncbi.nlm.nih.gov/pubmed/28792090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13767
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