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Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

Quinone‐based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4‐benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutan...

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Foilsithe in:Mol Microbiol
Main Authors: Meredith, Emma Louise, Kumar, Ambika, Konno, Aya, Szular, Joanna, Alsford, Sam, Seifert, Karin, Horn, David, Wilkinson, Shane R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656836/
https://ncbi.nlm.nih.gov/pubmed/28792090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13767
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