Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs

The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide de...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Bot, Chris, Hall, Belinda S., Bashir, Noosheen, Taylor, Martin C., Helsby, Nuala A., Wilkinson, Shane R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944584/
https://ncbi.nlm.nih.gov/pubmed/20679506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00800-10
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi