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Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs
The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide de...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology (ASM)
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944584/ https://ncbi.nlm.nih.gov/pubmed/20679506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00800-10 |
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