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Validation of spermidine synthase as a drug target in African trypanosomes
The trypanocidal activity of the ODC (ornithine decarboxylase) inhibitor DFMO (difluoromethylornithine) has validated polyamine biosynthesis as a target for chemotherapy. As DFMO is one of only two drugs used to treat patients with late-stage African trypanosomiasis, the requirement for additional d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2427175/ https://ncbi.nlm.nih.gov/pubmed/17916066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20071185 |
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