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Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation
Benznidazole, a 2-nitroimidazole, is the front-line treatment used against American trypanosomiasis, a parasitic infection caused by Trypanosoma cruzi. Despite nearly 40 years of use, the trypanocidal activity of this prodrug is not fully understood. It has been proposed that benznidazole activation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256028/ https://ncbi.nlm.nih.gov/pubmed/22037852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05135-11 |
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