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Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation
Benznidazole, a 2-nitroimidazole, is the front-line treatment used against American trypanosomiasis, a parasitic infection caused by Trypanosoma cruzi. Despite nearly 40 years of use, the trypanocidal activity of this prodrug is not fully understood. It has been proposed that benznidazole activation...
Wedi'i Gadw mewn:
| Prif Awduron: | , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Society for Microbiology
2012
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256028/ https://ncbi.nlm.nih.gov/pubmed/22037852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05135-11 |
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